P3.02b-038 Molecular Dynamics Simulation of EFGR L844V Mutant Sensitive to AZD9291 in Non-Small Cell Lung Cancer
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منابع مشابه
456ppreclinical Evidence and Clinical Cases of Azd9291 Activity in Egfr-mutant Non-small Cell Lung Cancer (nsclc) Brain Metastases (bm).
D. Kim1, J. Yang2, D. Cross3, P. Ballard4, P. Yang5, J. Yates6, L. Xie5, M. Cantarini7, S. Ghiorghiu7, P.A. Janne8 Department of Internal Medicine, Seoul National University Hospital (SNUH)-Yongon Campus, Seoul, KOREA Department of Oncology, National Taiwan University Hospital, Taipei, TAIWAN Oncology iMed, AstraZeneca, Macclesfield, UK iMed Oncology, AstraZeneca, Macclesfield, UK Innovation Ce...
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Osimertinib (OSI, also known as AZD9291) is the newest FDA-approved epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for non-small cell lung cancer (NSCLC) patients with EGFR T790M mutation. However, resistance to OSI is likely to progress and the study of potential OSI-resistant mechanisms in advanced is necessary. Here, the OSI-resistant NCI-H1975/OSIR cells were established....
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ژورنال
عنوان ژورنال: Journal of Thoracic Oncology
سال: 2017
ISSN: 1556-0864
DOI: 10.1016/j.jtho.2016.11.1705